{"id":7841,"date":"2025-02-25T22:31:05","date_gmt":"2025-02-26T01:31:05","guid":{"rendered":"https:\/\/mestrado.cmmg.edu.br\/linha-de-pesquisa\/medicina-translacional\/"},"modified":"2025-07-08T16:09:13","modified_gmt":"2025-07-08T19:09:13","slug":"medicina-translacional","status":"publish","type":"linha-de-pesquisa","link":"https:\/\/mestrado.cmmg.edu.br\/en\/linha-de-pesquisa\/medicina-translacional\/","title":{"rendered":"Translational medicine"},"content":{"rendered":"\t\t
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Translational medicine<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Epidemiological study of chronic degenerative diseases in the adult and elderly population of Brazil.<\/p>

This investigation includes the various aspects involved in the functionality and burden of chronic diseases, such as social, demographic, environmental, and behavioral risk factors, healthy life expectancy, total mortality, and premature death, morbidity (prevalence and incidence), clinical aspects (diagnosis, severity, response to treatment), and burden of disease YLL \u2013 years of life lost, YDL \u2013 years lived with disability, \u2013 disability-adjusted life years (DALY).YLLYLL\u2013 years of life lost,\u2013 years of life lost, YDLYDL \u2013 years lived with disability, \u2013 disability adjusted life years (\u2013 years lived with disability, \u2013 disability adjusted life years ( DALYDaly).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Research Axes<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Check out the Axes: <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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  • Axis: <\/b>Therapy of chronic non-communicable diseases<\/span><\/li>\n<\/ul>\n
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    1. Development of clinical and preclinical studies of drugs for the treatment and prevention of chronic non-communicable diseases (such as cardiovascular, metabolic, psychiatric, and ophthalmic diseases).<\/li>\n<\/ol>\n
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      • Axis: Pharmacology of pain and inflammation<\/b><\/li>\n<\/ul>\n
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        1. Characterization of inflammatory and painful changes associated with chronic diseases (diabetes, fibromyalgia, multiple sclerosis, arthritis, and migraine).<\/li>\n
        2. Investigation of new biochemical and molecular mechanisms of action in chronic pain treatment (phytotherapeutics, nutraceuticals, and toxins).<\/li>\n<\/ol>\n
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          • Axis: Neuropharmacology<\/span><\/li>\n<\/ul>\n
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            1. Investigation of new treatments and mechanisms in psychosomatic and neuropsychiatric diseases (depression, anxiety, autism, ADHD).<\/li>\n
            2. Characterization of the intestinal microbiota in the involvement and association of neuropsychiatric diseases.<\/li>\n<\/ol>\n
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              • Axis: Wound healing<\/span><\/li>\n<\/ul>\n
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                1. Involvement of therapies in tissue repair with therapeutic options through Hyperbaric Medicine and other formulations (mineral colloids and biofilms) that provide the repair of chronic wounds.<\/li>\n
                2. Involvement of therapies in tissue repair with therapeutic options through Hyperbaric Medicine and other formulations (mineral colloids and biofilms) that provide the repair of chronic wounds.<\/li>\n<\/ol>\n
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                  • Axis: Health of the elderly and functionality<\/span><\/li>\n<\/ul>\n
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                    1. Study chronic musculoskeletal diseases and the health of the elderly with a focus on translational and clinical studies applied to Geriatrics.<\/li>\n
                    2. Development of systematic reviews in health in general.<\/li>\n<\/ol>\n
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                      • Axis: Orthopedic health conditions: diagnosis, evaluation and treatment<\/span><\/li>\n<\/ul>\n
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                        1. Main musculoskeletal conditions related to pathophysiology, diagnosis, evaluation strategy, and treatment of translational studies applied to Orthopedics and Geriatrics.<\/li>\n
                        2. Basic experimental, clinical, methodological, and systematic review studies are developed.<\/li>\n<\/ol>\n
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                          • Axis: Ophthalmological diseases<\/span><\/li>\n<\/ul>\n
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                            1. Study the impact of ophthalmological diseases and their repercussions on vision and quality of life.<\/li>\n<\/ol>\n
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                              • Axis: Corneal transplantation<\/span><\/li>\n<\/ul>\n
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                                1. Study of different techniques, advantages, and disadvantages for treating corneal blindness.<\/li>\n<\/ol>\n
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                                  • Axis: Intraocular lenses<\/span><\/li>\n<\/ul>\n
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                                    1. Study of different models, optical quality, materials, designs, and biocompatibility.<\/li>\n<\/ol>\n
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                                      • Axis: Diagnosis and prognosis<\/span><\/li>\n<\/ul>\n
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                                        1. Correlation between infectious and parasitic diseases and chronic degenerative\/oncological diseases.<\/li>\n
                                        2. Identification of immune response profiles of infectious and parasitic diseases capable of assisting in the diagnosis and prognosis of associated chronic degenerative\/oncological diseases in different biological samples.<\/li>\n<\/ol>\n
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                                          • Axis: Biotechnology applied to the development of new diagnostic kits and vaccines<\/span><\/li>\n<\/ul>\n
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                                            1. Identification using biotechnological tools of new biomarkers of infectious and parasitic diseases.<\/li>\n
                                            2. Evaluation of new biomarkers of infectious and parasitic diseases capable of assisting in the diagnosis and prognosis of associated chronic degenerative\/oncological diseases.<\/li>\n
                                            3. Development and validation of new immunodiagnostic kits that assist in clinical practice.<\/li>\n
                                            4. Evaluating the preventive vaccine\/immunotherapeutic potential of selected infectious and parasitic disease antigens.<\/li>\n<\/ol>\n
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                                              • Axis: Pain<\/span><\/li>\n<\/ul>\n
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                                                1. The initial line of research studies and evaluates degenerative disease of the cervical and lumbar intervertebral disc in the elderly population associated with pain.<\/li>\n
                                                2. Studying and evaluating the impact of pharmacological interventions on pain, with an emphasis on quality of life and muscle performance in humans and the geriatric population.<\/li>\n
                                                3. Implementing the psychometric measures of the instruments used to assess pain, quality of life scales, daily activities, functionality measures, and muscle performance in elderly people with degenerative osteoarticular, muscular, and neurological diseases.<\/li>\n<\/ol>\n
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                                                  • Axis: Neurosciences<\/span><\/li>\n<\/ul>\n
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                                                    1. Line of research dedicated to validating questionnaires and scales used in research. It studies assessment instruments and pharmacological therapeutic interventions in degenerative and cognitive neurological diseases and dementia, postural instability, and difficulty walking in the elderly.<\/li>\n<\/ol>\n
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                                                      • Axis: Skin healing and keloid treatments<\/span><\/li>\n<\/ul>\n
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                                                        1. Repair time for chronic wounds and surgical wounds.<\/li>\n
                                                        2. Atrophic scars, stretch marks, hypertrophic scars, and keloids.<\/li>\n
                                                        3. Wound and scar treatments: dressings, medications, hyperbaric therapy.<\/li>\n
                                                        4. Treatments for atrophic, hypertrophic scars and keloids; drugs for topical, systemic, and intralesional use.<\/li>\n
                                                        5. Technologies (laser, pulsed light, LED, microneedling, radiofrequency) used in scar and wound treatments.<\/li>\n
                                                        6. Wound biology: histological, immunological and molecular aspects.<\/li>\n<\/ol>\n
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                                                          • Axis: Pain and inflammation on the functionality of the elderly<\/b><\/li>\n<\/ul>\n
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                                                            1. To assess the impact of non-pharmacological interventions on pain, functionality, and muscle performance in elderly animals and humans.<\/li>\n
                                                            2. The aim is to measure and verify the impact of exercise-induced myokines and other pro- and anti-inflammatory mediators on pain disorders, immunosenescence, and muscle and functional performance in the elderly.<\/li>\n
                                                            3. To verify the psychometric measures of the instruments used to assess pain, functionality, and muscle performance in the elderly with osteoarticular, muscular, and neurological diseases.<\/li>\n
                                                            4. To study the multidimensional aspects of the assessment, prevention, and treatment of low back pain in the elderly.<\/li>\n<\/ol>\n
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                                                              • Axis: Strategies for assessing, preventing, and treating health conditions in the elderly<\/span><\/li>\n<\/ul>\n
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                                                                1. To study the assessment instruments and non-pharmacological therapeutic interventions for cognitive changes and dementia, postural instability, sphincter incontinence, immobility, and family insufficiency in the elderly.<\/li>\n
                                                                2. To assess and intervene in the loss of intrinsic capacity, frailty syndrome, and sarcopenia in the elderly.<\/li>\n<\/ol>\n
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                                                                  • Axis: Cellular and molecular neuroscience<\/span><\/li>\n<\/ul>\n
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                                                                    1. To research muscle functionality and performance after orthopedic surgeries in the elderly.<\/li>\n
                                                                    2. To develop studies on osteoporosis, osteosarcopenia, and fragility fractures.<\/li>\n<\/ol>\n
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                                                                      •   <\/span>Axis: <\/b>Clinical neuroscience<\/span><\/li>\n<\/ul>\n
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                                                                        1. Investigate the clinical benefits of new therapeutic interventions for neuropsychiatric diseases.<\/li>\n
                                                                        2. Investigate clinical and laboratory biomarkers of interest for the diagnosis of neuropsychiatric diseases.<\/li>\n<\/ol>\n
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                                                                          • Axis: Cellular and molecular neuroscience<\/span><\/li>\n<\/ul>\n
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                                                                            1. Identify new neural pathways associated with affective and cognitive manifestations of relevance in neuropsychiatric syndromes.<\/li>\n
                                                                            2. Investigate the potential of procedures based on optical technology (optogenetics) for the therapy of neuropsychiatric diseases.<\/li>\n
                                                                            3. Investigate the effect of gene therapy on the symptoms of neuropsychiatric diseases.<\/li>\n
                                                                            4. Investigate the preclinical effects of new treatments for neuropsychiatric diseases.<\/li>\n<\/ol>\n
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                                                                              • Axis: Nephropathies and kidney transplantation<\/span><\/li>\n<\/ul>\n
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                                                                                1. Study of chronic kidney disease in all its aspects and stages; treatment modalities: dialysis and transplantation; clinical outcomes after kidney transplantation and risk factors associated with reduced graft and patient survival.<\/li>\n<\/ol>\n
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                                                                                  • Axis: Role of adipocytokines in ovarian steroidogenesis<\/span><\/li>\n<\/ul>\n
                                                                                           1.  The main objective of this project is to investigate the role of various adipocytokines in androgen production. <\/span>vitro<\/i> using a human adrenal cell line and bovine theca cells.<\/span><\/div>\n

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                                                                                    • Axis: <\/span>In-hospital prognostic factors and mortality in chronic diseases<\/span><\/li>\n<\/ul>\n
                                                                                             1. This line aims, through a cohort study, to investigate in individuals over 60 years of age admitted to HUCM, the main nutritional, sociodemographic, and clinical factors related to in-hospital mortality rates, and mortality and readmission.<\/span><\/div>\n

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